Research database

Project information
Hazardous substances
Project title
Transformation properties and environmental risk associated with pharmaceutical residues in the Arctic
Project leader
Roland Kallenborn

Anuschka Polder, Jan. L. Lyche (NMBU)

Nicholas Warner, Vladimir Nikiforov, Dorte Herzke (NILU, Tromsø); Terje Vasskog (NORUD), Geir. W. Gabrielsen, Heli Routti (NPI), Anita Evenset, Guttorm Christensen (APN); Zoya Zharkovskaya, Yana Russkikh, Ekaterina Chernova (SRCES RAS).

Hazardous Substances
Funding Source

Flagship "Hazardous substances" = 200 kNOK

UNIS (Pollutants on Svalbard) = 50 kNOK

Summary of Results

During the initial phaseof the project a new method vor QUEChERS bsed muliticompound analysis of relevant pharamceuticals was developed as a part of a still ongoing Masters project at NMBU/UNIS (Siri Havstein Aspnes). The method validation, 2.5 L sewage water from the outlet of Longyearbyen (Svalbard was collected in June 2015). The Water samples were extracted with a already established high volum solid phase method on HLB columns (WATERS, Milford, CA)  after filtration (Whatman, GF/C 24 mm, 1.2 um pore). Aliquots of 2 sewage water samples and one blank samples are currently analysed for the following substances at NMBU, NORUD and evt. NILU:  Metronidazole, Ciprofloxacin, Ketoprofen, Trimetoprim, Prednisolone , Sulfamethoxazole , Tetracycline, Penicillin G; 13C3 koffein is used as Internal. standard. In addition, the following substances are purchased as stanards for the extention of the method after a QUEChERS apporach is established during winter 2015/2016: Ethinyl Estradiol, Atorvastatin, Acetgyl Salicylcic acid, Simvastatin, Metoprolol, Lorsatan, Amlodipine, Zopiclone as well as 13C-Ibuprofen as additional Internal standard.

The method currently under development is based on the study by Cerquerira et al. (Cerqueira M.B.R., Guiherme J.R., Caldas S.S., MArtins M.L:, Zanella R., Primel E.G. (2014) Evalaution of QuEChERS mehod for the extraction of pharmaceuticals and personal care products from drinking water treatment sludge with determination by UPLC-ESI-MS/MS. Chemosphere 1007:74-82.) The method will be available for application in early spring 2016.

Plans for 2015: Representative samples from three Arctic locations (Effluent, influent and biota) will be collected from three Norwegian Arctic settlements/ towns: Tromsø, Longyearbyen, Kirkenes.T he QuEChERS based method will be applied and distribution profiles will be determined. The method will be refined and implemented into the analytical  programs of NORUD, NILU and NMBU. A first environmental toxicological study will be performed in close collaboration with our Russian partners from SRCES RAS). Preferably, the study will be performed as MSc project in close collaboration with all partners involv ed.

For the Management

Currently the focus of the initial year is laid on chemical analysis. We expect, that the entire project group will be involved during the application and sample collection phase in 2016.

Published Results/Planned Publications

no published results

Communicated Results

no comunication results

Interdisciplinary Cooperation

Collaboration between enviromental analytical chemists, enviromental toxicologists as well as regulation atuhorities already established. In addition, the Local sanitation experts in the respective sampling location willb e actively involved during field work.

Budget in accordance to results

The economic frame is still in accordance with the expected budget.

Could results from the project be subject for any commercial utilization
If Yes

not applicable


The project is planned as a pilot study specifically aiming at validating methods for characterization of biochemical transformation processes and assessment of environmental effects.A QuEcHERS based multi compound analysis method is currently under development and will be applied in sample materias (Sewage, effuent, biota) from three Arctic locations. The filed work is planned for 2016.